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  • Pharmacology and mode of action of Mitragyna speciosa Kratom
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    • An introduction to Kratom / Mitragyna speciosa
    • The Kratom and the Kratom plant: Mitragyna speciosa
    • Forms and types of Mitragyna speciosa Kratom
    • Pharmacology and mode of action of Mitragyna speciosa Kratom
    • The effects of Kratom / Mitragyna speciosa
    • Modern uses of Mitragyna speciosa Kratom and potential applications
    • Using Mitragyna speciosa Kratom
    • Guidelines for a safe and pleasant use of Mitragyna speciosa Kratom
    • Health risks and side-effects of Mitragyna speciosa Kratom use
    • Addiction potential of Mitragyna speciosa Kratom
    • The history and legality of Kratom / Mitragyna speciosa
    • Definitions
    • Selected bibliography on Mitragyna speciosa Kratom and Kratom alkaloids

  • Recent Articles

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    Selected bibliography on Mitragyna speciosa Kratom and Kratom alkaloids

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    A brief political history of Mitragyna speciosa Kratom

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    Where is Mitragyna speciosa Kratom legal / illegal?

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    Is Mitragyna speciosa Kratom habit-forming or not?

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    Mitragyna speciosa Kratom and drug testing

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  • Pharmacology and mode of action of Mitragyna speciosa Kratom RSS Feed

    Pharmacology and mode of action of Mitragyna speciosa Kratom 

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    Published on 12-20-2009 04:19 AM

    Mitragyna speciosa Kratom is most commonly classified as a “non-opioid narcotic”, yet this classification only partially ...
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    What are Mitragyna speciosa Kratom’s main psychoactive constituents? 

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    Published on 12-20-2009 04:19 AM

    The Mitragyna species are very rich in active compounds, and over 40 alkaloids have already been isolated in the leaves of its various species. Mitragyna speciosavar. Korthals has over 25 reported active alkaloids.
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    Mitragynine 

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    Published on 12-20-2009 04:19 AM

    Mitragynine is an indole alkaloid with the molecular formula C23H30N2O4. It is the most abundant active alkaloid in the plant Kratom plant Mitragyna speciosa, and was therefore first thought to be responsible for the plant’s activity, before 7-hydroxymitragynine was looked into, and proved to be much more potent.
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    7-hydroxymitragynine 

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    Published on 12-20-2009 04:19 AM

    Mitragynine was once thought to be Mitragyna speciosaKratom’s main active ingredient, yet more recently it has been found that the main active constituent is in fact more likely to be the potent 7-hydroxy derivative of mitragynine:7-hydroxymitragynine
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    Other Mitragyna speciosa Kratom alkaloids 

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    Published on 12-20-2009 04:19 AM

    Most of the alkaloids identified in Mitragyna speciosaKratom are Yohimbe-type indoles and oxindoles. The most abundant alkaloids consist of three indoles and two oxindoles, and some indoles such as mitragynine, paynanthine and others are unique to the Mitragyna speciosa plant.
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    List of alkaloids identified in Mitragyna speciosa Kratom, and their known or potential activity 

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    Published on 12-20-2009 04:19 AM

    Concentration percentages given come from different studies of alkaloid concentrations in Mitragyna speciosa- Kratom leaf. Some of the alkaloids given in this list still need to be studied more specifically in order to determine their potential activity.
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